In eukaryotes, activator proteins bind to _____; generalized transcription factors bind to _____7/5/2023 A banded krait minor (Bkm) satellite DNA, consisting of highly conserved GATA repeats, which is arranged in a sex-specific manner, is hypervariable. However, recent discoveries of trinucleotide repeat expansion mutations associated with at least four human genetic diseases, several short repeats acting as motifs for binding of various transcription factors, and several minisatellite-binding nuclear proteins, which are expressed in specific tissues and bind to specific sequences, strongly suggest that different families of minisatellites may have different functions. Based on this, a generalized function of minisatellites to provide binding sites for recombination proteins in eukaryotes has also been suggested. These contain a core sequence resembling the chi sequence of Escherichia coli, which is a binding site for recombination proteins. Minisatellites are tandemly repeated, highly variable DNA sequences found in most higher eukaryotes.
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